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No distinct dose adjustment advised when tofacitinib coadministered with strong CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with both equally average CYP3A4 and powerful CYP2C19 inhibitors .posaconazole will increase the degree or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor